Sodium Hydroxide → 1198437-54-5

HRID 244676Notes

Reaction equation

HRID 244676 reaction equation
[CH3:1][CH:2]([N:4]1[C:8]([C:9]([O:11]CC)=[O:10])=[CH:7][N:6]=[N:5]1)[CH3:3].[OH-].[Na+]>CO>[CH3:3][CH:2]([N:4]1[C:8]([C:9]([OH:11])=[O:10])=[CH:7][N:6]=[N:5]1)[CH3:1]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 58356337HCID 58356337, compound

Product 1

HCID 583564111198437-54-5Yield 75%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
20 °C

Procedure

To a solution of ethyl 1-(1-methylethyl)-1H-1,2,3-triazole-5-carboxylate (0.315 g) in methanol (5 ml) was added sodium hydroxide (5 ml) and the mixture stirred at 20° C. for 18 h. The solvent was removed in vacuo and the residue taken up in water (5 ml) and acidified with 2M hydrochloric acid. The mixture was extracted with ethyl acetate and dried over sodium sulphate then filtered and evaporated to give the title compound (0.2 g) a white solid.

Workup

  1. customThe solvent was removed in vacuo
  2. extractionThe mixture was extracted with ethyl acetate
  3. dry with materialdried over sodium sulphate
  4. filtrationthen filtered
  5. customevaporated

Sources & evidence

ORD record
ord-d6c5aaab542c4a5da21d5228117558be
Source dataset
uspto-grants-2014_02
Patent number
US08658635B2

Reaction notes

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