Dichloromethane → HCID 178440579, compound

Participants

Reaction Steps

2-(1,1-Dimethylethyl)-1H-pyrrolo[2,3-b]pyridine (10 g, 57 mmol) was dissolved in ethyl acetate:DCM (400 ml, 1:1, v/v), cooled to ˜0° C. in an ice bath and treated by dropwise addition of m-chloroperbenzoic acid (15.85 g, 69.5 mmol). The reaction was warmed to room temperature over 3 hours then treated with 30% potassium carbonate (aq) (150 ml). The organic layer was separated and the aqueous washed with further DCM (2×100 ml). The combined organic layers were washed with a sodium metabisulphite solution, dried then evaporated to give title compound, 11.1 g.

Provenance & Evidence