HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 244688Generated: October 25, 2026
Thionyl Chloride → 1,4-Dimethyl-1H-pyrazole-3-carbonyl chloride
https://huagongshe.com/reaction/244688
Participants
| Role | Name | HCID | Charge |
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| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 1,4-Dimethyl-1H-pyrazole-3-carboxylic acid | HCID 5325685 | — |
| Product | 1,4-Dimethyl-1H-pyrazole-3-carbonyl chloride | HCID 58356380 | — |
Reaction Steps
Thionyl chloride (4 ml) was added to 1,4-dimethyl-1H-pyrazole-3-carboxylic acid (0.5 g) and the reaction was heated at 80° C. for 2 h. Further thionyl chloride (2 ml) was added and the reaction was heated at 80° C. for 1 h. The reaction was evaporated, then azeotroped with toluene to give title compound, 511 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08658635B2 |
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| Source dataset | uspto-grants-2014_02 |
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| ORD ID | ord-45674eb3d94748a3b78460a3aeb10509 |
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| Source note | uspto-grants-2014_02 |
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