反应详情

温度

90 °C

2-(Chloromethyl)-N-{1-(phenylsulfonyl)-6-[1-(phenylsulfonyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-1H-indazol-4-yl}-1,3-thiazole-4-carboxamide (53 mg, 0.077 mmol) and (2R,6S)-2,6-dimethylmorpholine (0.5 ml, 0.077 mmol) were placed in a microwave vial and heated in a microwave at 90° C. for 15 min, allowed to cool, then heated again in the microwave at 90° C. for 15 min. A further portion of (2R,6S)-2,6-dimethylmorpholine (0.3 ml) was added and the mixture was heated in the microwave at 90° C. for 30 mins. Volatiles were removed under a stream of nitrogen to give the title compound as a pale yellow solid (99 mg). The material was used without further purification.

1. temperatureto cool
2. temperatureheated again in the microwave at 90° C. for 15 min
3. temperaturethe mixture was heated in the microwave at 90° C. for 30 mins
4. customVolatiles were removed under a stream of nitrogen