反应详情

温度

150 °C

N-(6-Bromo-1H-indazol-4-yl)-2-methyl-1,3-thiazole-4-carboxamide (50 mg), Pd(dppf)Cl2 (12 mg), 2M sodium carbonate (0.222 ml), 1,4-dioxane (1 ml) and water (1 ml) were added to 1H-indol-5-ylboronic acid (29 mg) in a microwave vial. The vial was sealed and heated under microwave irradiation at 150° C. for 15 min. The reaction mixture was extracted with DCM (2×20 ml) and then separated, combined organic layers were evaporated to dryness. The residue was dissolved in methanol:DMSO (1 ml, 1:1) and purified by mass directed preparative HPLC (Method A) to give title compound (3.7 mg).

1. customThe vial was sealed
2. extractionThe reaction mixture was extracted with DCM (2×20 ml)
3. customseparated
4. customwere evaporated to dryness
5. dissolutionThe residue was dissolved in methanol
6. customDMSO (1 ml, 1:1) and purified by mass