HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 244740Generated: October 30, 2026
Sodium Carbonate → HCID 67319636, compound
https://huagongshe.com/reaction/244740
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | (2-tert-Butyl-1H-pyrrolo[2,3-b]pyridin-4-yl)boronic acid | HCID 57416476 | — |
| Reactant | N-(6-bromo-1H-indazol-4-yl)-2-methyl-1,3-thiazole-4-carboxamide | HCID 58255750 | — |
| Catalyst | HCID 178418807 | HCID 178418807 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 67319636 | HCID 67319636 | — |
Reaction Steps
N-(6-Bromo-1H-indazol-4-yl)-2-methyl-1,3-thiazole-4-carboxamide (50 mg), Pd(dppf)Cl2-DCM adduct (12 mg), 2 M sodium carbonate (aq) (0.22 ml), 1,4-dioxane (0.5 ml) and water (0.278 ml) were added to [2-(1,1-dimethylethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]boronic acid (39 mg). The reaction was heated under microwave irradiation at 150° C. for a total of 25 min. The reaction was passed through a silica cartridge, preconditioned with MeOH, washing with MeOH. The solvent was evaporated and the residue purified using the following system:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08658635B2 |
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| Source dataset | uspto-grants-2014_02 |
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| ORD ID | ord-cb68a2b3ab93472eb05b3e4b7e53a65a |
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| Source note | uspto-grants-2014_02 |
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