Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzyl Bromide → 8-Benzyloxy-3-methyl-1H-quinolin-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzyl Bromide | HCID 7498 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 3-Methyl-quinolin-2,8-diol | HCID 440986 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | 8-Benzyloxy-3-methyl-1H-quinolin-2-one | HCID 22499223 | — |
반응 단계
Benzyl bromide (1.28 mL) is added to a suspension of potassium carbonate (2.98 g) in a solution of 8-hydroxy-3-methyl-1H-quinolin-2-one (1.26 g) in acetone (36 mL) at room temperature. The reaction mixture is refluxed for 18 hours, filtered, evaporated and purified by flash column chromatography on silica gel, eluting with 2% methanol in dichloromethane.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08658673B2 |
| 출처 데이터셋 | uspto-grants-2014_02 |
| ORD ID | ord-9335fb91b5654477aa63ba31b8ec8888 |
| 출처 메모 | uspto-grants-2014_02 |