HRID244790

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCc1cc2c(cc1CC)CC(NC[C@@H](O)c1ccc(OCc3ccccc3)c3[nH]c(=O)ccc13)C2

HCID9826559

未命名化合物

结构：O=[N+]([O-])c1cc([C@@H]2CO2)ccc1OCc1ccccc1

HCID10880191

(R)-2-(4-(Benzyloxy)-3-nitrophenyl)oxirane

C15H13NO4

HCID22499261

未命名化合物

PRODUCTS

生成物

结构：CC1(N(Cc2ccccc2)C[C@H](O)c2ccc(OCc3ccccc3)c([N+](=O)[O-])c2)Cc2ccccc2C1

HCID66822916

未命名化合物

PROCEDURE

实验过程

The title compound is prepared from (R)-2-(4-benzyloxy-3-nitro-phenyl)-oxirane (2.52 g) and benzyl-(2-methyl-indan-2-yl)-amine (2.20 g) by an analogous procedure to that used to prepare (S)-8-Benzyloxy-5-[2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-1H-quinolin-2-one in Example 19. The reaction is shown to be complete by TLC after 24 hours. The product is purified by flash column chromatography (silica, n-hexane/ethyl acetate 4:1). TLC (silica, n-hexane/ethyl acetate 4:1 Rf=0.30).

WORKUP

后处理

customThe product is purified by flash column chromatography (silica, n-hexane/ethyl acetate 4:1)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a257d8d00c644e75a20f4c55a4952994
来源数据集: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08658673B2
来源说明: uspto-grants-2014_02

反应 SMILES

[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C@@H:15]2[CH2:17][O:16]2)=[CH:11][C:10]=1[N+:18]([O-:20])=[O:19])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:21]([NH:28][C:29]1([CH3:38])[CH2:37][C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH2:30]1)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.C(OC1C=CC([C@H](O)CNC2CC3C(=CC(CC)=C(CC)C=3)C2)=C2C=1NC(=O)C=C2)C1C=CC=CC=1>>[CH2:21]([N:28]([C:29]1([CH3:38])[CH2:37][C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH2:30]1)[CH2:17][C@@H:15]([C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[C:10]([N+:18]([O-:20])=[O:19])[CH:11]=1)[OH:16])[C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1