HRID244816

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCOCc1nc2cnc3cc(/C=C/CCN4C(=O)c5ccccc5C4=O)ccc3c2n1CCCOC(C)C

HCID69084200

未命名化合物

PRODUCTS

生成物

HCID69081406

未命名化合物

收率 99.8%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID702

Ethanol

C2H6O

2 次

PROCEDURE

实验过程

2-{(3E)-4-[2-ethoxymethyl-1-(3-isopropoxypropyl)-1H-imidazo[4,5-c]quinolin-7-yl]but-3-enyl}-1H-isoindole-1,3(2H)-dione (1.9 g, 3.6 mmol) was dissolved in ethanol (50 mL) and added to a Parr flask containing 10% palladium on carbon (0.3 g) wetted with ethanol. The flask was degassed three times, charged with hydrogen (50 psi) and shaken for 16 hours. The catalyst was removed by filtration through CELITE filter agent. Concentration of the filtrate under reduced pressure provided 1.9 g of 2-{4-[2-ethoxymethyl-1-(3-isopropoxypropyl)-1H-imidazo[4,5-c]quinolin-7-yl]butyl}-1H-isoindole-1,3(2H)-dione as a pale yellow oil.

WORKUP

后处理

additionadded to a Parr flask
customThe flask was degassed three times
additioncharged with hydrogen (50 psi)
customThe catalyst was removed by filtration through CELITE
filtrationfilter agent

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-205a6d5e0f914bb3a296fb93a357eac6
来源数据集: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08658666B2
来源说明: uspto-grants-2014_02

反应 SMILES

[CH2:1]([O:3][CH2:4][C:5]1[N:6]([CH2:33][CH2:34][CH2:35][O:36][CH:37]([CH3:39])[CH3:38])[C:7]2[C:16]3[CH:15]=[CH:14][C:13](/[CH:17]=[CH:18]/[CH2:19][CH2:20][N:21]4[C:29](=[O:30])[C:28]5[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=5)[C:22]4=[O:31])=[CH:12][C:11]=3[N:10]=[CH:9][C:8]=2[N:32]=1)[CH3:2]>C(O)C.[Pd]>[CH2:1]([O:3][CH2:4][C:5]1[N:6]([CH2:33][CH2:34][CH2:35][O:36][CH:37]([CH3:38])[CH3:39])[C:7]2[C:16]3[CH:15]=[CH:14][C:13]([CH2:17][CH2:18][CH2:19][CH2:20][N:21]4[C:22](=[O:31])[C:23]5[C:28](=[CH:27][CH:26]=[CH:25][CH:24]=5)[C:29]4=[O:30])=[CH:12][C:11]=3[N:10]=[CH:9][C:8]=2[N:32]=1)[CH3:2]