HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 244966Generated: October 25, 2026
4-Aminophenol → 2-(4-Hydroxyphenylamino)-2-methylpropanenitrile
https://huagongshe.com/reaction/244966
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Aminophenol | HCID 403 | — |
| Reactant | Acetone Cyanohydrin | HCID 6406 | — |
| Reactant | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| Product | 2-(4-Hydroxyphenylamino)-2-methylpropanenitrile | HCID 350269 | 96% |
Reaction Steps
A mixture of 4-aminophenol (1.09 g, 10 mmol), acetone cyanohydrin (10 ml) and MgSO4 (2 g) was heated to 80° C. and stirred for 4 h. After concentration of the medium under vacuum, compound 3a was crystallized from water (20 ml). The solid was filtered and dried to yield 2-(4-hydroxyphenylamino)-2-methylpropanenitrile, 3a (1.69 g, 9.6 mmol, 96%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08658681B2 |
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| Source dataset | uspto-grants-2014_02 |
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| ORD ID | ord-5642086b16d940f4847fbde5012c6f54 |
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| Source note | uspto-grants-2014_02 |
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