HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → 4-methyl-3-(3-methyl-1H-indol-2-ylmethylene)-1,3-dihydro-indol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 3-Methyl-1H-indole-2-carbaldehyde | HCID 277260 | — |
| Reactant | 4-Methyl-1,3-dihydro-2H-indol-2-one | HCID 12579382 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-methyl-3-(3-methyl-1H-indol-2-ylmethylene)-1,3-dihydro-indol-2-one | HCID 54480851 | — |
Reaction Steps
A mixture of 4-methyl-2-oxindole (147 mg), 3-methyl-indole-2-carbaldehyde (190 mg) (prepared according to Synthetic Communications, 1986, 16, 1799) and piperidine (10 mg) in ethanol was held in a sealed tube at 95° C. for 4 hours. The mixture was cooled to room temperature. The solid was collected by vacuum filtration, washed with cold ethanol and dried in a vacuum oven to give 4-methyl-3-(3-methyl-1H-indol-2-ylmethylene)-1,3-dihydro-indol-2-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06855730B2 |
| Source dataset | uspto-grants-2005_02 |
| ORD ID | ord-bd4d01409cd2464db5c5ca42380c9ee2 |
| Source note | uspto-grants-2005_02 |