HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → 1-(Methylamino)cyclopentane-1-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Cyclopentanone | HCID 8452 | — |
| Reactant | Trimethylsilyl cyanide | HCID 82115 | — |
| Product | 1-(Methylamino)cyclopentane-1-carbonitrile | HCID 12945445 | — |
Reaction Steps
Methylamine was bubbled into a refrigerated mixture of cyclopentanone (0.252 g, 3 mmol) and trimethylsilyl cyanide (0.396 g, 4 mmol) until the volume doubled. The mixture was stirred 3 h and then concentrated to dryness to obtain 31a (0.372 g, quantitative).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08658681B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-119af7ba7e6c4db489fe77419c0a430b |
| Source note | uspto-grants-2014_02 |