反应详情

A mixture of 3-(2-Formyl-4,5,6,7-tetrahydro-1H-indol-3-yl)-propionic acid (3.4 g), 2.7 g of 5-bromo-2-oxindole and 1.4 g of pyrrolidine in 25 mL of ethanol was refluxed for 4 hours. Upon slow addition of acetic acid (8 mL), a precipitate formed. The mixture was refluxed for 5 minutes and cooled to ambient temperature. The precipitate was collected by vacuum filtration and washed with 20 mL of ethanol. The solids were slurry-washed by refluxing in 30 mL of ethanol, cooled, collected by vacuum filtration, washed with 30 mL of ethanol and dried under vacuum to give 5.2 g (98% yield) of 3-[2-(5-bromo-2-oxo-1,2-dihydroindol-3-ylidenemethyl)-4,5,6,7-tetrahydro-1H-indol-3-yl]-propionic acid as a red-orange solid, mp 286-289° C.

1. temperaturewas refluxed for 4 hours
2. customa precipitate formed
3. temperatureThe mixture was refluxed for 5 minutes
4. filtrationThe precipitate was collected by vacuum filtration
5. washwashed with 20 mL of ethanol
6. washThe solids were slurry-washed
7. temperatureby refluxing in 30 mL of ethanol
8. temperaturecooled
9. filtrationcollected by vacuum filtration
10. washwashed with 30 mL of ethanol
11. customdried under vacuum