反应详情

A mixture of 3-(2-formyl-4,5,6,7-tetrahydro-1H-indol-3-yl)-propionic acid (5.4 g), 3.7 g of 6-chloro-2-oxindole and 2.7 g of piperidine in 25 mL of ethanol was refluxed for 4 hours. Upon slow addition of acetic acid (8 mL), a precipitate formed. The mixture was refluxed for 5 minutes and cooled to ambient temperature. The precipitate was collected by vacuum filtration and washed with 20 mL of ethanol. The solids were slurry-washed in 30 mL of reflushing ethanol, cooled, collected by vacuum filtration, washed with 30 mL of ethanol and vacuum dried to give 6.5 g (80%) of 3-[2-(6-chloro-2-oxo-1,2-dihydroindol-3-ylidenemethyl)-4,5,6,7-tetrahydro-1H-indol-3-yl]-propionic acid as an orange solid.

1. temperaturewas refluxed for 4 hours
2. customa precipitate formed
3. temperatureThe mixture was refluxed for 5 minutes
4. filtrationThe precipitate was collected by vacuum filtration
5. washwashed with 20 mL of ethanol
6. washThe solids were slurry-washed in 30 mL of reflushing ethanol
7. temperaturecooled
8. filtrationcollected by vacuum filtration
9. washwashed with 30 mL of ethanol and vacuum
10. customdried