2-Chloro-3-ethyl-4-fluorobenzonitrile → 2-Chloro-3-ethyl-4-[[(1S)-2-hydroxy-2-methyl-cyclopentyl]amino]benzonitrile

Participants

Reaction Steps

2-Chloro-3-ethyl-4-[[(1S)-2-hydroxy-2-methyl-cyclopentyl]amino]benzonitrile is prepared essentially as described in Example 1 using (2S)-2-amino-1-methyl-cyclopentanol hydrochloride (Preparation 18) and 2-chloro-3-ethyl-4-fluoro-benzonitrile. The crude material (350 mg) is purified using silica gel chromatography (20-60% EtOAc/hexane) to obtain Diastereomer 1 (cis) (82 mg) and Diastereomer 2 (trans) (29 mg).

Provenance & Evidence