2-Methoxy-6-(3-methyl-butyl)-isonicotinic acid → (S)-3-(2-Ethyl-4-{5-[2-methoxy-6-(3-methyl-butyl)-pyridin-4-yl]-[1,2,4]oxadiazol-3-yl}-6-methyl-phenoxy)-propane-1,2-diol

Participants

Reaction Steps

The title compound is prepared in analogy to Example 1 starting from 2-methoxy-6-(3-methyl-butyl)-isonicotinic acid and (R)-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-3-ethyl-N-hydroxy-5-methyl-benzamidine; LC-MS: tR=1.14 min, [M+H]+=456.16; 1H NMR (CDCl3): δ 1.00 (d, J=6.3 Hz, 6H), 1.33 (t, J=7.5 Hz, 3H), 1.64-1.74 (m, 3H), 2.41 (s, 3H), 2.77 (q, J=7.5 Hz, 2H), 2.81-2.86 (m, 2H), 3.82-3.94 (m, 2H), 3.94-3.98 (m, 2H), 4.03 (s, 3H), 4.14-4.21 (m, 1H), 7.32 (d, J=0.8 Hz, 1H), 7.49 (d, J=0.8 Hz, 1H), 7.88 (s, 1H), 7.89 (s, 1H).

Provenance & Evidence