2-(1-Ethylpropyl)-6-methoxyisonicotinic acid → N-(2-Ethyl-4-{5-[2-(1-ethyl-propyl)-6-methoxy-pyridin-4-yl]-[1,2,4]oxadiazol-3-yl}-6-methyl-phenyl)-methanesulfonamide

Participants

Reaction Steps

The title compound (24 mg) is prepared in analogy to Example 11 starting from 2-(1-ethyl-propyl)-6-methoxy-isonicotinic acid (32 mg, 143 μmol) and 3-ethyl-N-hydroxy-4-methanesulfonylamino-5-methyl-benzamidine (40 mg, 150 mmol); LC-MS**: tR=0.91 min, [M+H]+=459.09; 1H NMR (CDCl3): δ0.85 (t, J=7.3 Hz, 6H), 1.36 (t, J=7.3 Hz, 3H), 1.69-1.89 (m, 4H), 2.56 (s, 3H), 2.57-2.65 (m, 1H), 2.93 (q, J=7.5 Hz, 2H), 3.18 (s, 3H), 4.02 (s, 3H), 5.92 (s, 1H), 7.33 (s, 1H), 7.44 (s, 1H), 7.97 (s, 1H), 7.99 (s, 1H).

Provenance & Evidence