N-bromobutanimide → Methyl 3-(bromomethyl)-6-(methylsulfonyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Participants

Reaction Steps

Methyl 3-methyl-6-(methylsulfonyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate (1.22 g, 2.88 mmol), NBS (0.667 g, 3.75 mmol) and diphenylperoxyanhydride (0.070 g, 0.288 mmol) in carbon tetrachloride (50 mL) were heated to 100° C. and stirred overnight. The mixture was cooled to room temperature, and the solvent was removed in vacuo to afford methyl 3-(bromomethyl)-6-(methylsulfonyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate. This material was used without further purification. MS (m/z) 502.0 (M+H+).

Provenance & Evidence