反应详情

To a 100 mL flask charged with 27 mL of chlorosulfonic acid was slowly added 13.3 g of 2-oxindole. The reaction temperature was maintained below 30° C. during the addition. After the addition, the reaction mixture was stirred at room temperature for 1.5 hr, heated to 68° C. and stirred an additional 1 hr, cooled, and poured into water. The precipitate was washed with water and dried in a vacuum oven to give 11.0 g of 5-chlorosulfonyl-2-oxindole (50% yield) which was used without further purification.

1. temperatureThe reaction temperature was maintained below 30° C. during the addition
2. additionAfter the addition
3. temperatureheated to 68° C.
4. stirringstirred an additional 1 hr
5. temperaturecooled
6. washThe precipitate was washed with water
7. customdried in a vacuum oven