反应详情

温度

100 °C

A mixture of methyl 7-(ethyloxy)-6-(ethylsulfonyl)-3-methyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate (9.11 g, 18.92 mmol), N-bromosuccinimide (4.38 g, 24.60 mmol) and diphenylperoxyanhydride (0.458 g, 1.892 mmol) in carbon tetrachloride (100 mL) was heated to 100° C. overnight. The mixture was cooled to room temperature and the solvent was removed under reduced pressure to afford methyl 3-(bromomethyl)-7-(ethyloxy)-6-(ethylsulfonyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate. This material was used without further purification. MS (m/z) 562.0 (M+H+).

1. temperatureThe mixture was cooled to room temperature
2. customthe solvent was removed under reduced pressure