反应详情

温度

100 °C

To a suspension of methyl 3-methyl-6-(methylsulfonyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate (2.66 g, 6.28 mmol) in carbon tetrachloride (41.9 mL) was added N-bromosuccinimide (1.454 g, 8.17 mmol) and benzoyl peroxide (0.152 g, 0.628 mmol). The resulting mixture was heated at 100° C. for 18 h. The mixture was cooled to room temperature and concentrated in vacuo to afford methyl 3-(bromomethyl)-6-(methylsulfonyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate. This material was used without further purification.

1. temperatureThe mixture was cooled to room temperature
2. concentrationconcentrated in vacuo