Potassium Hydroxide → HCID 67383517, compound

Participants

Reaction Conditions

Reaction Steps

Potassium hydroxide (0.364 g, 6.50 mmol) was added to a suspension of methyl 6-(ethylsulfonyl)-7-(methyloxy)-3-{[4-(1-pyrrolidinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate (0.805 g, 1.299 mmol) in methanol (12.99 mL) and water (4.33 mL). The mixture was heated to 65° C. for 3 d. The reaction mixture was cooled to room temperature, concentrated in vacuo, diluted with water (5 mL), and acidified to pH 4-5 with 2N HCl. The resulting precipitate was collected by filtration and dried to afford 6-(ethylsulfonyl)-7-(methyloxy)-3-{[4-(1-pyrrolidinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid (0.487 g, 59% yield) as a tan solid. MS (m/z) 606.2 (M+H+).

Provenance & Evidence