HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 24530Generated: October 29, 2026
Piperidine → ethyl (E)-3-[(2-oxo-1,2-dihydroindol-3-ylidenemethyl)phenyl]propionate
https://huagongshe.com/reaction/24530
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Oxindole | HCID 321710 | — |
| Reactant | Ethyl 3-(2-formylphenyl)prop-2-enoate | HCID 53401261 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | ethyl (E)-3-[(2-oxo-1,2-dihydroindol-3-ylidenemethyl)phenyl]propionate | HCID 86591008 | 37.3% |
Reaction Steps
A mixture of 1 g of ethyl 3-(2-formylphenyl)propenate, 500 mg oxindole and 0.1 mL piperidine in 5 mL of ethanol was stirred at 90° C. overnight. The mixture was evaporated and purified on a silica gel column to give 450 mg of ethyl (E)-3-[(2-oxo-1,2-dihydroindol-3-ylidenemethyl)phenyl]propionate (M+1=322).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06855730B2 |
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| Source dataset | uspto-grants-2005_02 |
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| ORD ID | ord-15c001fb00a64568a6ec8ef3bf9b38a8 |
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| Source note | uspto-grants-2005_02 |
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