Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonium formate → 3-Fluoro-4-morpholinoaniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonium formate | HCID 2723923 | — |
| 반응물 | 4-(2-Fluoro-4-nitrophenyl)morpholine | HCID 2905489 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 3-Fluoro-4-morpholinoaniline | HCID 1485330 | 95% |
반응 단계
10% Pd—C 4.0 g was added to 3-fluoro-4-morpholinyl nitrobenzene (40 g, 177 mmol), ammonium formate (50 g, 793 mmol) in 200 mL of ethyl acetate and stirred at 45˜50° C. for 8 h until the completion of the reaction. The mixture was then filtrated and separated by water. The organic layer was washed with brine and dried over anhydrous magnesium sulfate, filtered, and the solvent was evaporated to provide 33 g of solid in 95% yield.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08658789B2 |
| 출처 데이터셋 | uspto-grants-2014_02 |
| ORD ID | ord-1c93aff449f8492a9eec693a741f577d |
| 출처 메모 | uspto-grants-2014_02 |