Dibenzylamine → (S)-1-chloro-3-(dibenzylamino)propan-2-ol

Participants

Reaction Steps

Dibenzylamine (39.4 g, 0.20 mol) and lithium bromide (1.7 g, 20 mmol) were added to 100 mL ethyl acetate and stirred for 30 minutes. (S)-epichlorohydrin (21 g, 0.23 mol) was then added. The reaction went on at room temperature (32° C.) for 2 hours. Filtered, and the solvent was evaporated to provide 53 g of colorless oil with 90% yield.

Provenance & Evidence