HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 245312Generated: October 26, 2026
Dibenzylamine → (S)-1-chloro-3-(dibenzylamino)propan-2-ol
https://huagongshe.com/reaction/245312
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dibenzylamine | HCID 7656 | — |
| Reactant | (+)-Epichlorohydrin | HCID 149428 | — |
| Catalyst | Calcium Chloride | HCID 5284359 | — |
| Product | (S)-1-chloro-3-(dibenzylamino)propan-2-ol | HCID 49765557 | 98.3% |
Reaction Steps
Dibenzylamine (39.4 g, 0.20 mol) and calcium chloride (1 g, 9 mmol) were added to (S)-epichlorohydrin (185 g, 2 mol). The mixture was stirred at room temperature (33° C.) for 8 hours. Filtered, and the solvent was evaporated to provide 57 g of colorless oil in 97% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08658789B2 |
|---|
| Source dataset | uspto-grants-2014_02 |
|---|
| ORD ID | ord-86602fe82f0e4d8cb98ebfdb162b72bd |
|---|
| Source note | uspto-grants-2014_02 |
|---|
