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Nitrogen → (5S)-5-(Aminomethyl)-3-(3-fluoro-4-(4-morpholinyl)phenyl)-2-oxazolidinone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Nitrogen | HCID 947 | — |
| 反応物 | (S)-5-((dibenzylamino)methyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one | HCID 11213668 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | (5S)-5-(Aminomethyl)-3-(3-fluoro-4-(4-morpholinyl)phenyl)-2-oxazolidinone | HCID 10780199 | 93.1% |
反応手順
(S)-5-((dibenzylamino)methyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one (0.95 g, 2 mmol) and 0.5 g of 10 wt % Pd—C were added to 20 mL acetone and the air was replaced with N2. The reaction stirred under 5 Mpa hydrogen at room temperature (25° C.) for 5 hours. Filtered and the solvent was evaporated to provide 0.55 g of white solid in 93% yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08658789B2 |
| 出典データセット | uspto-grants-2014_02 |
| ORD ID | ord-b84c9af834694565ac940682c03fe0d3 |
| 出典メモ | uspto-grants-2014_02 |