Dibenzylamine → (S)-1-chloro-3-(dibenzylamino)propan-2-ol

Participants

Reaction Conditions

Reaction Steps

Dibenzylamine (39.4 g, 0.20 mol) and stannic chloride (78.3 g. 0.30 mol) were added to 100 mL of acetone. The mixture was stirred at 25° C. for 30 minutes. (S)-epichlorohydrin (18.6 g, 0.2 mol) was then added and stirred at 60° C. for 8 hours. The mixture was filtered and the solvent was evaporated to provide 55 g of colorless oil with 94% yield. HPLC: 99.2%.

Provenance & Evidence