HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 245327Generated: October 31, 2026
Dibenzylamine → (S)-1-chloro-3-(dibenzylamino)propan-2-ol
https://huagongshe.com/reaction/245327
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dibenzylamine | HCID 7656 | — |
| Reactant | (+)-Epichlorohydrin | HCID 149428 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | (S)-1-chloro-3-(dibenzylamino)propan-2-ol | HCID 49765557 | 94.9% |
Reaction Steps
Dibenzylamine (39.4 g, 0.20 mol) and ferric chloride (12.6 g. 0.30 mol) were added to 100 mL of acetonitrile. The mixture was stirred at 25° C. for 30 minutes. (S)-epichlorohydrin (18.6 g, 0.2 mol) was then added and stirred at 60° C. for 8 hours. Filtered and the solvent was evaporated to provide 55 g of colorless oil in 94% yield. HPLC: 98%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08658789B2 |
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| Source dataset | uspto-grants-2014_02 |
|---|
| ORD ID | ord-32d89b4277e1457f985d1c0b2d1b2a94 |
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| Source note | uspto-grants-2014_02 |
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