反应详情

温度

50 °C

(S)-5-(aminomethyl)-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one acetate (3.5 g, 10 mmol) was dissolved in 20 mL of water. The solution was heated to 50° C. and then acetic anhydride (0.72 g, 12 mmol) was added dropwise and stirred at 50° C. for 2 hours. The mixture was cooled down to 0° C. to crystallize, filtered, washed with water, dried and recrystallized with ethyl acetate to provide 3.0 g of Linezolid in 88% yield.

1. temperatureThe mixture was cooled down to 0° C.
2. customto crystallize
3. filtrationfiltered
4. washwashed with water
5. customdried
6. customrecrystallized with ethyl acetate