反应详情

4.23 g (35.0 mmol) of valeroyl chloride (compound of the formula VI) were added with cooling at −10° C. to 20° C. to a stirred suspension of 11.3 g (34.7 mmol) of 2-(2-hydroxy-5-nitrophenyl)-1-(4-methoxyphenyl)-ethanone potassium salt (example 1) in 50 ml of dry acetone. After 30 minutes the reaction was complete, as monitored by LC-MS, and the mixture was filtered through a layer of Celite to remove the precipitated potassium chloride. The solution was evaporated to dryness to give 9.23 g (98%) of a yellow oil which slowly crystallized while standing at room temperature.

1. filtrationthe mixture was filtered through a layer of Celite
2. customto remove the precipitated potassium chloride
3. customThe solution was evaporated to dryness