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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 245388Generated: October 26, 2026

3-Pyridinecarboxaldehyde → {5-({[tert-butyl(diphenyl)silyl]oxy}methyl)-3-chloro-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2-fluorophenyl}(pyridin-3-yl)methanol

https://huagongshe.com/reaction/245388

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-PyridinecarboxaldehydeHCID 10371—
ReactantLithium diisopropylamideHCID 2724682—
Reactant(2R,6S)-[6-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-chloro-3-fluorophenyl]-2,6-dimethylmorpholineHCID 67359669—
Product{5-({[tert-butyl(diphenyl)silyl]oxy}methyl)-3-chloro-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2-fluorophenyl}(pyridin-3-yl)methanolHCID 86717854—

Reaction Steps

Starting material: (2R,6S)-4-[6-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-chloro-3-fluorophenyl]-2,6-dimethylmorpholine (Intermediate 42), pyridine-3-carboaldehyde and LDA

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08658641B2
Source datasetuspto-grants-2014_02
ORD IDord-5ed57a8d1abb43ecbda8995789671659
Source noteuspto-grants-2014_02