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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 245390Generated: October 25, 2026

1-Methyl-2-imidazolecarboxaldehyde → 5-({[tert-butyl(diphenyl)silyl]oxy}methyl-3-chloro-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2-fluorophenyl}(1-methyl-1H-imidazol-2-yl)methanol

https://huagongshe.com/reaction/245390

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Methyl-2-imidazolecarboxaldehydeHCID 139575—
Reactant(2R,6S)-[6-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-chloro-3-fluorophenyl]-2,6-dimethylmorpholineHCID 67359669—
ReactantButyllithiumHCID 178418339—
Product5-({[tert-butyl(diphenyl)silyl]oxy}methyl-3-chloro-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2-fluorophenyl}(1-methyl-1H-imidazol-2-yl)methanolHCID 131731210—

Reaction Steps

Starting material: (2R,6S)-4-[6-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-chloro-3-fluorophenyl]-2,6-dimethylmorpholine (Intermediate 42), 1-methyl-imidazole-2-carbaldehyde and n-BuLi

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08658641B2
Source datasetuspto-grants-2014_02
ORD IDord-85cf89e197624021b342fbdc6e275468
Source noteuspto-grants-2014_02