HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-methyl-1H-imidazole-5-carbaldehyde → {5-({[tert-butyl(diphenyl)silyl]oxy}methyl)-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2,3-difluorophenyl}(1-methyl-1H-imidazol-5-yl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-methyl-1H-imidazole-5-carbaldehyde | HCID 573592 | — |
| Reactant | (2R,6S)-4-(6-((tert-butyldiphenylsilyloxy)methyl)-2,3-difluorophenyl)-2,6-dimethylmorpholine | HCID 67357593 | — |
| Reactant | CID 53628100 | HCID 178418400 | — |
| Product | {5-({[tert-butyl(diphenyl)silyl]oxy}methyl)-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2,3-difluorophenyl}(1-methyl-1H-imidazol-5-yl)methanol | HCID 86658060 | — |
Reaction Steps
Starting materials: (2R,6S)-4-[6-({[tert-butyl(diphenyl) silyl]oxy}methyl)-2,3-difluorophenyl]-2,6-dimethylmorpholine (Intermediate 3), 1-methyl-imidazole-5-carbaldehyde (116 mg, 1.06 mmol) and sec-butyllithium.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08658641B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-da7bd4812dbe40c58ba29fc8d3ea4df9 |
| Source note | uspto-grants-2014_02 |