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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 245405Generated: October 25, 2026

N-Methoxy-6,N-dimethyl-nicotinamide → 5-({[tert-butyl(diphenyl)silyl]oxy}methyl-3-chloro-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2-fluorophenyl}(6-methylpyridin-3-yl)methanone

https://huagongshe.com/reaction/245405

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-Methoxy-6,N-dimethyl-nicotinamideHCID 11367353—
Reactant(2R,6S)-[6-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-chloro-3-fluorophenyl]-2,6-dimethylmorpholineHCID 67359669—
Product5-({[tert-butyl(diphenyl)silyl]oxy}methyl-3-chloro-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2-fluorophenyl}(6-methylpyridin-3-yl)methanoneHCID 131731211—

Reaction Steps

Starting materials: (2R,6S)-4-[6-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-chloro-3-fluorophenyl]-2,6-dimethylmorpholine (Intermediate 42) and N-methoxy-6,N-dimethyl-nicotinamide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08658641B2
Source datasetuspto-grants-2014_02
ORD IDord-b4bf3b1c42724f8daa64c42e7356f741
Source noteuspto-grants-2014_02