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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 245406Generated: October 26, 2026

N-Methoxy-N-methylpyrimidine-2-carboxamide → 5-({[tert-butyl(diphenyl)silyl]oxy}methyl-3-chloro-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2-fluorophenyl}(pyrimidin-2-yl)methanone

https://huagongshe.com/reaction/245406

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-Methoxy-N-methylpyrimidine-2-carboxamideHCID 22498726—
Reactant(2R,6S)-[6-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-chloro-3-fluorophenyl]-2,6-dimethylmorpholineHCID 67359669—
Product5-({[tert-butyl(diphenyl)silyl]oxy}methyl-3-chloro-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2-fluorophenyl}(pyrimidin-2-yl)methanoneHCID 131731212—

Reaction Steps

Starting materials: (2R,6S)-4-[6-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-chloro-3-fluorophenyl]-2,6-dimethylmorpholine (Intermediate 42) and N-methoxy-N-methylpyrimidine-2-carboxamide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08658641B2
Source datasetuspto-grants-2014_02
ORD IDord-865bc4f27861423a92e2d3996e0a8344
Source noteuspto-grants-2014_02