Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 245419Generated: October 26, 2026

N-Methoxy-6,N-dimethyl-nicotinamide → (5-((tert-butyldiphenylsilyloxy)methyl)-4-((2R,6S)-2,6-dimethylmorpholino)-2,3-difluorophenyl)(6-methylpyridin-3-yl)methanone

https://huagongshe.com/reaction/245419

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-Methoxy-6,N-dimethyl-nicotinamideHCID 11367353—
Reactant(2R,6S)-4-(6-((tert-butyldiphenylsilyloxy)methyl)-2,3-difluorophenyl)-2,6-dimethylmorpholineHCID 67357593—
Product(5-((tert-butyldiphenylsilyloxy)methyl)-4-((2R,6S)-2,6-dimethylmorpholino)-2,3-difluorophenyl)(6-methylpyridin-3-yl)methanoneHCID 86658073—

Reaction Steps

Starting materials (2R,6S)-4-(6-((tert-butyldiphenylsilyloxy)methyl)-2,3-difluorophenyl)-2,6-dimethylmorpholine (Intermediate 3 and N-methoxy-N, 6-dimethylnicotinamide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08658641B2
Source datasetuspto-grants-2014_02
ORD IDord-de96b4d30b2642ff99e5890b98f68f5b
Source noteuspto-grants-2014_02