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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 245424Generated: November 1, 2026

2,2-Difluoro-N-methoxy-N-methylacetamide → 1-(5-((tert-butyldiphenylsilyloxy)methyl)-4-((2R,6S)-2,6-dimethylmorpholino)-2,3-difluorophenyl)-2,2-difluoroethanone

https://huagongshe.com/reaction/245424

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,2-Difluoro-N-methoxy-N-methylacetamideHCID 19023731—
Reactant(2R,6S)-4-(6-((tert-butyldiphenylsilyloxy)methyl)-2,3-difluorophenyl)-2,6-dimethylmorpholineHCID 67357593—
Product1-(5-((tert-butyldiphenylsilyloxy)methyl)-4-((2R,6S)-2,6-dimethylmorpholino)-2,3-difluorophenyl)-2,2-difluoroethanoneHCID 86658078—

Reaction Steps

Starting materials: (2R,6S)-4-(6-((tert-butyldiphenylsilyloxy)methyl)-2,3-difluorophenyl)-2,6-dimethylmorpholine (Intermediate 3) and 2,2-difluoro-N-methoxy-N-methylacetamide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08658641B2
Source datasetuspto-grants-2014_02
ORD IDord-c5018efc4b154aa5996e09f252819857
Source noteuspto-grants-2014_02