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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 245425Generated: November 1, 2026

2,2,2-Trifluoro-N-methoxy-N-methylacetamide → 1-(5-((tert-butyldiphenylsilyloxy)methyl)-4-((2R,6S)-2,6-dimethylmorpholino)-2,3-difluorophenyl)-2,2,2-trifluoroethanone

https://huagongshe.com/reaction/245425

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,2,2-Trifluoro-N-methoxy-N-methylacetamideHCID 2782382—
Reactant(2R,6S)-4-(6-((tert-butyldiphenylsilyloxy)methyl)-2,3-difluorophenyl)-2,6-dimethylmorpholineHCID 67357593—
Product1-(5-((tert-butyldiphenylsilyloxy)methyl)-4-((2R,6S)-2,6-dimethylmorpholino)-2,3-difluorophenyl)-2,2,2-trifluoroethanoneHCID 86658092—

Reaction Steps

Starting materials (2R,6S)-4-(6-((tert-butyldiphenylsilyloxy)methyl)-2,3-difluorophenyl)-2,6-dimethylmorpholine (Intermediate 3) and 2,2,2-trifluoro-N-methoxy-N-methylacetamide. Compound exists in the hydrated form.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08658641B2
Source datasetuspto-grants-2014_02
ORD IDord-1fb47c6bf1f048daae4821cbf3f1b1f9
Source noteuspto-grants-2014_02