Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 245426Generated: November 1, 2026

Tetrahydrofuran → (5-((tert-butyldiphenylsilyloxy)methyl)-4-((2R,6R)-2,6-dimethylmorpholino)-2,3-difluorophenyl)(thiazol-2-yl)methanone

https://huagongshe.com/reaction/245426

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTetrahydrofuranHCID 8028—
ReactantN-Methoxy-N-methyl-thiazole-2-carboxamideHCID 53408674—
Reactant(2R,6R)-4-(6-((tert-butyldiphenylsilyloxy)methyl)-2,3-difluorophenyl)-2,6-dimethylmorpholineHCID 67358084—
Solventtert-Butyl methyl etherHCID 15413—
Product(5-((tert-butyldiphenylsilyloxy)methyl)-4-((2R,6R)-2,6-dimethylmorpholino)-2,3-difluorophenyl)(thiazol-2-yl)methanoneHCID 86658079—

Reaction Steps

Starting materials (2R,6R)-4-(6-((tert-butyldiphenylsilyloxy)methyl)-2,3-difluorophenyl)-2,6-dimethylmorpholine (Intermediate 43) and N-methoxy-N-methylthiazole-2-carboxamide (MTBE was used as solvent instead of THF).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08658641B2
Source datasetuspto-grants-2014_02
ORD IDord-37e58bc2144f4341ae1a07e6a27e6d79
Source noteuspto-grants-2014_02