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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 245427Generated: November 2, 2026

Tetrahydrofuran → 1-(5-((tert-butyldiphenylsilyloxy)methyl)-4-((2R,6R)-2,6-dimethylmorpholino)-2,3-difluorophenyl)-2,2-difluoroethanone

https://huagongshe.com/reaction/245427

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTetrahydrofuranHCID 8028—
Reactant2,2-Difluoro-N-methoxy-N-methylacetamideHCID 19023731—
Reactant(2R,6R)-4-(6-((tert-butyldiphenylsilyloxy)methyl)-2,3-difluorophenyl)-2,6-dimethylmorpholineHCID 67358084—
Solventtert-Butyl methyl etherHCID 15413—
Product1-(5-((tert-butyldiphenylsilyloxy)methyl)-4-((2R,6R)-2,6-dimethylmorpholino)-2,3-difluorophenyl)-2,2-difluoroethanoneHCID 86658080—

Reaction Steps

Starting materials (2R,6R)-4-(6-((tert-butyldiphenylsilyloxy)methyl)-2,3-difluorophenyl)-2,6-dimethylmorpholine (Intermediate 43) and 2,2-difluoro-N-methoxy-N-methylacetamide (MTBE was used as solvent instead of THF).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08658641B2
Source datasetuspto-grants-2014_02
ORD IDord-3cdbddf96d5d48e9a1f14cdbf3630441
Source noteuspto-grants-2014_02