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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 245431Generated: October 25, 2026

N-Methoxy-N-methylnicotinamide → (6-((tert-butyldiphenylsilyloxy)methyl)-4-chloro-5-((2R,6S)-2,6-dimethylmorpholino)-3-fluoropyridin-2-yl)(pyridin-3-yl)methanone

https://huagongshe.com/reaction/245431

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-Methoxy-N-methylnicotinamideHCID 10558996—
Reactant(2R,6S)-4-(2-((tert-Butyldiphenylsilyloxy)methyl)-4-chloro-5-fluoropyridin-3-yl)-2,6-dimethylmorpholineHCID 67319975—
Product(6-((tert-butyldiphenylsilyloxy)methyl)-4-chloro-5-((2R,6S)-2,6-dimethylmorpholino)-3-fluoropyridin-2-yl)(pyridin-3-yl)methanoneHCID 67356797—

Reaction Steps

Starting material: (2R,6S)-4-(2-((tert-butyldiphenylsilyloxy)methyl)-4-chloro-5-fluoropyridin-3-yl)-2,6-dimethylmorpholine (Intermediate 45) and N-methoxy-N-methylnicotinamide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08658641B2
Source datasetuspto-grants-2014_02
ORD IDord-642d9770ff614920b786ab07112b2924
Source noteuspto-grants-2014_02