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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 245433Generated: October 31, 2026

N-Methoxy-N-methyl-thiazole-2-carboxamide → (6-((tert-butyldiphenylsilyloxy)methyl)-4-chloro-5-((2R,6S)-2,6-dimethylmorpholino)-3-fluoropyridin-2-yl)(thiazol-2-yl)methanone

https://huagongshe.com/reaction/245433

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-Methoxy-N-methyl-thiazole-2-carboxamideHCID 53408674—
Reactant(2R,6S)-4-(2-((tert-Butyldiphenylsilyloxy)methyl)-4-chloro-5-fluoropyridin-3-yl)-2,6-dimethylmorpholineHCID 67319975—
Product(6-((tert-butyldiphenylsilyloxy)methyl)-4-chloro-5-((2R,6S)-2,6-dimethylmorpholino)-3-fluoropyridin-2-yl)(thiazol-2-yl)methanoneHCID 67358160—

Reaction Steps

Starting material: (2-((tert-butyldiphenylsilyloxy)methyl)-4-chloro-5-fluoropyridin-3-yl)-2,6-dimethylmorpholine (Intermediate 45) and N-methoxy-N-methylthiazole-2-carboxamide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08658641B2
Source datasetuspto-grants-2014_02
ORD IDord-5d3d582b914948cab14680938dde9963
Source noteuspto-grants-2014_02