N-Methoxy-N,5-dimethylisoxazole-3-carboxamide → {5-({[tert-butyl(diphenyl)silyl]oxy}methyl)-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2,3-difluorophenyl}(5-methyl-1,2-oxazol-3-yl)methanone

Participants

Role	Name	HCID	Charge
Reactant	N-Methoxy-N,5-dimethylisoxazole-3-carboxamide	HCID 45099367	—
Reactant	(2R,6S)-4-(6-((tert-butyldiphenylsilyloxy)methyl)-2,3-difluorophenyl)-2,6-dimethylmorpholine	HCID 67357593	—
Product	{5-({[tert-butyl(diphenyl)silyl]oxy}methyl)-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2,3-difluorophenyl}(5-methyl-1,2-oxazol-3-yl)methanone	HCID 86658083	—

Reaction Steps

Starting materials: (2R,6S)-4-[6-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2,3-difluorophenyl]-2,6-dimethylmorpholine (Intermediate 3) and N-methoxy-N,5-dimethyl-1,2-oxazole-3-carboxamide

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08658641B2
Source dataset	uspto-grants-2014_02
ORD ID	ord-00ae48e1e9784651b44b3ee23f8d83c8
Source note	uspto-grants-2014_02