3,3-Difluoroazetidine hydrochloride → (3,3-Difluoroazetidin-1-yl)(5-(dimethoxymethyl)-6,7-difluorobenzo[d]isoxazol-3-yl)methanone

HRID 245473Notes

Reaction equation

HRID 245473 reaction equation
[CH3:1][O:2][CH:3]([O:20][CH3:21])[C:4]1[C:5]([F:19])=[C:6]([F:18])[C:7]2[O:11][N:10]=[C:9]([C:12]([O:14]CC)=O)[C:8]=2[CH:17]=1.Cl.[F:23][C:24]1([F:28])[CH2:27][NH:26][CH2:25]1>>[F:23][C:24]1([F:28])[CH2:27][N:26]([C:12]([C:9]2[C:8]3[CH:17]=[C:4]([CH:3]([O:2][CH3:1])[O:20][CH3:21])[C:5]([F:19])=[C:6]([F:18])[C:7]=3[O:11][N:10]=2)=[O:14])[CH2:25]1

Participants

3

Reactant 2

HCID 27582473,3-Difluoroazetidine hydrochlorideHCID 67360293Ethyl 5-(dimethoxymethyl)-6,7-difluorobenzo[d]isoxazole-3-carboxylate2×

Product 1

HCID 67358946(3,3-Difluoroazetidin-1-yl)(5-(dimethoxymethyl)-6,7-difluorobenzo[d]isoxazol-3-yl)methanone

Procedure

Starting materials: ethyl 5-(dimethoxymethyl)-6,7-difluorobenzo[d]isoxazole-3-carboxylate (Intermediate 206) and 3,3-difluoroazetidine hydrochloride.

Sources & evidence

ORD record
ord-8c0650ef832d4f61be5635fc5db17e29
Source dataset
uspto-grants-2014_02
Patent number
US08658641B2

Reaction notes

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