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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 245476Generated: October 29, 2026

Ethylamine → 5-((tert-Butyldiphenylsilyloxy)methyl)-7-chloro-6-((2R,6S)-2,6-dimethylmorpholino)-N-ethylisoxazolo[4,5-b]pyridine-3-carboxamide

https://huagongshe.com/reaction/245476

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthylamineHCID 6341—
ReactantEthyl 5-((tert-butyldiphenylsilyloxy)methyl)-7-chloro-6-((2R,6S)-2,6-dimethylmorpholino)isoxazolo[4,5-b]pyridine-3-carboxylateHCID 67356857—
Product5-((tert-Butyldiphenylsilyloxy)methyl)-7-chloro-6-((2R,6S)-2,6-dimethylmorpholino)-N-ethylisoxazolo[4,5-b]pyridine-3-carboxamideHCID 67432331—

Reaction Steps

Starting material: ethyl 5-((tert-butyldiphenylsilyloxy)methyl)-7-chloro-6-((2R,6S)-2,6-dimethylmorpholino)isoxazolo[4,5-b]pyridine-3-carboxylate (Intermediate 211) and ethylamine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08658641B2
Source datasetuspto-grants-2014_02
ORD IDord-252461cf939a469994731cfe37edc728
Source noteuspto-grants-2014_02