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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 245477Generated: October 29, 2026

Isopropylamine → 5-((tert-butyldiphenylsilyloxy)methyl)-7-chloro-6-((2R,6S)-2,6-dimethylmorpholino)-N-isopropylisoxazolo[4,5-b]pyridine-3-carboxamide

https://huagongshe.com/reaction/245477

Reaction equation

Participants

RoleNameHCIDCharge
ReactantIsopropylamineHCID 6363—
ReactantEthyl 5-((tert-butyldiphenylsilyloxy)methyl)-7-chloro-6-((2R,6S)-2,6-dimethylmorpholino)isoxazolo[4,5-b]pyridine-3-carboxylateHCID 67356857—
Product5-((tert-butyldiphenylsilyloxy)methyl)-7-chloro-6-((2R,6S)-2,6-dimethylmorpholino)-N-isopropylisoxazolo[4,5-b]pyridine-3-carboxamideHCID 67359642—

Reaction Steps

Starting material: ethyl 5-((tert-butyldiphenylsilyloxy)methyl)-7-chloro-6-((2R,6S)-2,6-dimethylmorpholino)isoxazolo[4,5-b]pyridine-3-carboxylate (Intermediate 211) and isopropylamine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08658641B2
Source datasetuspto-grants-2014_02
ORD IDord-a84b2691db974235b4579b8cdaffee51
Source noteuspto-grants-2014_02