trans-2,6-Dimethylmorpholine → HCID 86658099, compound

HRID 245484Notes

Reaction equation

HRID 245484 reaction equation
F[C:2]1[C:16]([CH:17]=[O:18])=[CH:15][C:5]2[C:6]([C:9]([NH:11][CH:12]([CH3:14])[CH3:13])=[O:10])=[N:7][O:8][C:4]=2[C:3]=1[F:19].[CH3:20][C@H:21]1[O:26][C@H:25]([CH3:27])[CH2:24][NH:23][CH2:22]1>>[CH3:27][C@@H:25]1[CH2:24][N:23]([C:2]2[C:16]([CH:17]=[O:18])=[CH:15][C:5]3[C:6]([C:9]([NH:11][CH:12]([CH3:14])[CH3:13])=[O:10])=[N:7][O:8][C:4]=3[C:3]=2[F:19])[CH2:22][C@@H:21]([CH3:20])[O:26]1

Participants

3

Reactant 2

HCID 11137133trans-2,6-DimethylmorpholineHCID 86658100HCID 86658100, compound2×

Product 1

HCID 86658099HCID 86658099, compound

Procedure

The title compound was prepared from 6,7-difluoro-5-formyl-N-isopropylbenzo[d]isoxazole-3-carboxamide (Intermediate 242) and (2R,6R)-2,6-dimethylmorpholine.

Sources & evidence

ORD record
ord-6e1ff16150b143b3b731d1adfc65f40a
Source dataset
uspto-grants-2014_02
Patent number
US08658641B2

Reaction notes

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