Cyclohexanemethylamine → HCID 67357557, compound

HRID 245487Notes

Reaction equation

[Si]([O:18][CH2:19][C:20]1[C:21]([N:35]2[CH2:40][C@H:39]([CH3:41])[O:38][C@H:37]([CH3:42])[CH2:36]2)=[C:22]([F:34])[C:23]2[O:27][N:26]=[C:25]([C:28]([O:30]CC)=O)[C:24]=2[CH:33]=1)(C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1.[CH:43]1([CH2:49][NH2:50])[CH2:48][CH2:47][CH2:46][CH2:45][CH2:44]1>>[CH:43]1([CH2:49][NH:50][C:28]([C:25]2[C:24]3[CH:33]=[C:20]([CH2:19][OH:18])[C:21]([N:35]4[CH2:36][C@H:37]([CH3:42])[O:38][C@H:39]([CH3:41])[CH2:40]4)=[C:22]([F:34])[C:23]=3[O:27][N:26]=2)=[O:30])[CH2:48][CH2:47][CH2:46][CH2:45][CH2:44]1

Participants

Reactant 2

HCID 76688Cyclohexanemethylamine

HCID 67357675ethyl 5-((tert-butyldiphenylsilyloxy)methyl)-6-((2R,6S)-2,6-dimethylmorpholino)-7-fluorobenzo[d]isoxazole-3-carboxylate2×

Product 1

HCID 67357557HCID 67357557, compound

Procedure

Starting materials: ethyl 5-((tert-butyldiphenylsilyloxy)methyl)-6-((2R,6S)-2,6-dimethylmorpholino)-7-fluorobenzo[d]isoxazole-3-carboxylate (Intermediate 204) and cyclohexylmethanamine

Sources & evidence

ORD record: ord-74fd2abb9a23482b94509fa2d7af889c
Source dataset: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08658641B2

Reaction notes

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