HCID 45122498, compound → HCID 67432320, compound

HRID 245493Notes

Reaction equation

[Si]([O:18][CH2:19][C:20]1[C:21]([N:35]2[CH2:40][C@H:39]([CH3:41])[O:38][C@H:37]([CH3:42])[CH2:36]2)=[C:22]([F:34])[C:23]2[O:27][N:26]=[C:25]([C:28](OCC)=[O:29])[C:24]=2[CH:33]=1)(C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1.[CH3:43][O:44][CH2:45][C:46]([CH2:51][O:52][CH3:53])([NH2:50])[CH2:47][O:48][CH3:49]>>[CH3:49][O:48][CH2:47][C:46]([NH:50][C:28]([C:25]1[C:24]2[CH:33]=[C:20]([CH2:19][OH:18])[C:21]([N:35]3[CH2:36][C@H:37]([CH3:42])[O:38][C@H:39]([CH3:41])[CH2:40]3)=[C:22]([F:34])[C:23]=2[O:27][N:26]=1)=[O:29])([CH2:51][O:52][CH3:53])[CH2:45][O:44][CH3:43]

Participants

Reactant 2

HCID 45122498HCID 45122498, compound

HCID 67357675ethyl 5-((tert-butyldiphenylsilyloxy)methyl)-6-((2R,6S)-2,6-dimethylmorpholino)-7-fluorobenzo[d]isoxazole-3-carboxylate2×

Product 1

HCID 67432320HCID 67432320, compound

Procedure

Starting materials: ethyl 5-((tert-butyldiphenylsilyloxy)methyl)-6-((2R,6S)-2,6-dimethylmorpholino)-7-fluorobenzo[d]isoxazole-3-carboxylate (Intermediate 204) and 1,3-dimethoxy-2-(methoxymethyl)propan-2-amine

Sources & evidence

ORD record: ord-8aca202a36a8490cb528f81a3fcda887
Source dataset: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08658641B2

Reaction notes

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